Effect of external use of sesame oil in the prevention of chemotherapy-induced phlebitis

Intravenous chemotherapy is an important mean for the treatment of cancers. Infusion phlebitis [Ph] is a common and acute complication of chemotherapy. The frequency of Ph is about 70% in patients undergoing chemotherapeutic management. It can induce the pain, increase the risk of thrombophlebitis, lead to incomplete follow-up, and thereby, affect the patient's health status. Respecting the great importance of these issues, it is essential to prevent Ph. This study conducted to determine the effect of external use of Sesame Oil [SO] in the prevention of Ph. Sixty patients with colon or rectum cancer, who admitted for chemotherapeutic management, enrolled in clinical trial and were randomly divided into two equal groups: Control and Intervention. Ten drops of SO was applied twice a day for 14 days externally in intervention group, whereas the control group received nothing. Incidence and grade of Ph was measured in both groups. Data was analyzed through independent t-test, X[2], Fisher's exact test, Mann-Whitney, and Lagrange survival using SPSS 16. The incidence of Ph was 10% and 80% in intervention group and control group, respectively.There was a significant difference between two groups [p < 0.05]. Ph was 8 times more frequent in control group [R R = 8; AR R = 70%]. In addition, there was statistically significant difference between the grade and incidence of Ph with SO and control group [p < 0.05]. According to these results, it seems that external use of SO is effective, safe and well-tolerated for prophylaxis from Ph. Therefore, it can be suggested as a selected prevention method for reducing the complication

Clinical application of Chamomilla recutita in phlebitis: dose response curve study / Aplicação clínica da Chamomilla recutita em flebites: estudo de curva dose-resposta / Aplicación clínica de la Chamomilla recutita en flebitis: estudio de la curva dosis-respuesta

This experimental and dose-response curve study aimed to carry out the quality control of the Chamomilla recutita sample, as well as to estimate the ideal dose, for anti-inflammatory effect, of the extract of its capitula, in patients with phlebitis due to peripheral intravenous infusion of antineoplastic chemotherapy and to evaluate the toxicity of this extract in human beings. The therapeutic efficacy, concerning the anti-inflammatory potential, of different doses of Chamomilla recutita extract were analyzed and compared in 25 patients. The time of regression of phlebitis was shorter for groups with 2.5 percent concentration (mean=29.2h, standard deviation = 8.98) and 5 percent concentration (mean = 38.8h, standard deviation = 17.47). Local toxicity was almost not observed. This research contributes to the innovation of the nursing clinical practice, since it suggests an alternative for the treatment of phlebitis through the clinical use of phytotherapeutic drugs.

Neste estudo, buscou-se realizar o controle de qualidade da amostra de Chamomilla recutita, bem como estimar a dose ideal, para efeito anti-inflamatório, do infuso dos seus capítulos florais, em pacientes com flebite, decorrente de infusão intravenosa periférica de quimioterapia antineoplásica, e avaliar a toxicidade desse infuso em seres humanos. Trata-se de estudo experimental, do tipo curva dose-resposta, no qual foi analisada e comparada a eficácia terapêutica, quanto ao potencial anti-inflamatório, de diferentes doses do infuso da Chamomilla recutita, em 25 pacientes. O tempo de regressão da flebite foi menor para os grupos com concentração 2,5 por cento (média=29,2h, desvio padrão=8,98) e 5 por cento (média=38,8h, desvio padrão=17,47) e praticamente não se observou toxicidade local. Esta pesquisa contribui para a inovação da prática clínica em enfermagem, uma vez que sugere alternativa para o tratamento de flebites, por meio da utilização clínica de fitoterápicos.

En este estudio, se buscó realizar el control de calidad de la muestra de Chamomilla recutita, así como estimar la dosis ideal, para efecto antiinflamatorio, de la infusión de sus inflorescencias, en pacientes con flebitis proveniente de introducción intravenosa periférica de quimioterapia antineoplásica y evaluar la toxicidad de esta infusión en los seres humanos. Se trata de estudio experimental, del tipo curva dosis-respuesta, en el cual fue analizada y comparada la eficacia terapéutica, en cuanto al potencial antiinflamatorio, de diferentes dosis de la infusión de la Chamomilla recutita en 25 pacientes. El tiempo de regresión de la flebitis fue menor para los grupos con concentración 2,5 por ciento (promedio = 29,2h, desviación estándar = 8,98) y 5 por ciento (promedio = 38,8h, desviación estándar = 17,47) y prácticamente no se observó toxicidad local. Esta investigación contribuye para la innovación de la práctica clínica en enfermería, una vez que sugiere una alternativa para el tratamiento de la flebitis por medio de la utilización clínica de fitoterapéuticos.

Flebitis séptica: origen de cuadros sépticos graves / Septic phlebitis: report of two cases

We report two patients, an 82 yeers old female and a 71 years old male, who bad a severe sepis with positive blood cultures for Staphylococcus aureis and a superficial phlebitis as the only probable focus. In both, the diagnosis of septic phlebitis was reached and an emergency phlebotomy was performed under local anaesthesia. The clinical response was satÝsfactory and the pathological examination of excised veins showed an acute exudative leukocytic thrombophlebitis

Factores de riesgo para flebitis por infusión de nutrición parental periférica / Risks factors for infusion phlebitis in patient with peripheral parenteral nutrition

La flebitis asociada a infusión es extremadamente frecuente. Este fenómeno causa, además de molestias al paciente, aumento en costos, por requerir cambios frecuentes de los accesos venosos. Se ha propuesto que la flebitis ocurre en alguna de las siguientes formas. La más frecuente, es producto del efecto químico de agentes diluídos en los fluídos de infusión forma de partículas. Un segundo tipo es el resultado delefecto físico del trauma inducido por la colocación del catéter a nivel intravenoso, y finalmente la forma microbiana, producida por bacterias introducidas en la piel durante el procedimiento o producto de fluídos contaminados.

Eficacia e seguranca do extrato seco da semente de castanha-da India no traamento da insuficiencia venosa cronica de membros inferiores / Efficacy and safety on use of dried horse chestnut extract in the treatmente of chronic venous insufficiency of the limbs.

This is a double-blind, randomized, placebo-controled, parallel study of the use of dried horse chestnut extract (Venostasin Retard) inchronic venous insufficiency of the limbs. Fifty-one patients were enrolled, divided in two groups, active (N=25) and placebo (N=26), and received treatment fortwenty days. The following parameters were evaluated: telangiectasy, perimaleolar oedema, disestesy vascular congestion, blood ebling, ocre dermatitis, ulceration, burning, lead-footfeeling, effort incapacity, and others like pains or itching. Almost all these parameters showed a statistically significant improvement or a strong trend of improvement in the active group, except telangiectasy, perimaleolar oedema and ulceration. Adverse effects were unfrecquent and mild. In conclusion, the dried horse chestnut extract (Venostasin Retard) was efficaciuos regarding to the treatment of chronic venous insuciency of the limbs, and presented hight levels of safety and tolerance